Schematic representation of activated and inhibited Wnt/?-catenin pathway. “WNT ON point out?? On ligation of Wnts for their receptors made up of frizzled proteins and LRP5/6, the cytoplasmic protein DVL is activated and induces the suppression of GSK3?. Subsequently, stabilized ?-catenin translocates in to the nucleus and binds to TCF/LEF transc